The algorithm performed by PIRCHE.org for the Prediction of Indirectly ReCognized HLA Epitopes (PIRCHE) was invented by Eric Spierings, University Medical Center Utrecht (UMCU), The Netherlands. UMC Utrecht Holding B.V., has filed a patent, pending patent application no: PCT/EP2009/006053. For further information see following PIRCHE related publications:
- H.G. Otten, J.J. Calis, C. Keşmir, A.D. van Zuilen, and E. Spierings, “Predicted indirectly recognizable HLA epitopes presented by HLADR correlate with the de novo development of donor-specific HLA IgG antibodies after kidney transplantation.” Human Immunology 2013; 74, no. 3, 290-296.
- K.A Thus, L. te Boome, J. Kuball and E. Spierings, ”Indirectly recognized HLA-C mismatches and their potential role in transplant outcome.” Frontiers in Immunology 2014; fimmu-05-00210.
- K. Geneugelijk, K. A. Thus and E. Spierings, “Predicting alloreactivity in transplantation.” Journal of Immunology Research, 2014, Article ID 159479.
- K.A. Thus, M.T.A. Ruizendaal, T.A. de Hoop, E. Borst, H.W.M. van Deutekom, L. te Boome, J. Kuball and E. Spierings. “Refinement of the Definition of Permissible HLA-DPB1 Mismatches with Predicted Indirectly ReCognizable HLA-DPB1 Epitopes.“ Biology of Blood and Marrow Transplantation 2014; 06.026.
PIRCHE.org is referencing to IMGT/HLA Database and herewith we want to give credit to the authors:
- Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE The IMGT/HLA Database Nucleic Acids Research (2013) 41:D1222-7
- Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE: IMGT/HLA – a sequence database for the human major histocompatibility complex Tissue Antigens (2000), 55:280-28
Prediction of Indirectly ReCognized HLA Epitopes (PIRCHE) is a new algorithm to estimate the potential of a T-cell related graft versus host immune response against mismatching HLA after transplantation. The PIRCHE-Module is based on a published and patent pending (application no: PCT/EP2009/006053) algorithm.
2. Access to PIRCHE – Module
3. Scope of Services
3.1 Use of PIRCHE-Module
The PIRCHE-Module service is for research use only.
The PIRCHE algorithm was invented by Eric Spierings, Ph.D. University Medical Center Utrecht (UMCU), The Netherlands. We require any user publishing scientific work using the PIRCHE-Module to give credit to Eric Spierings by citing his most suitable latest publication and by citing the website www.PIRCHE.org.
3.2 Users Restrictions
Consumers are not allowed to register. A consumer means every natural person who enters into a legal transaction for a purpose that is outside his trade, business or profession.
4. Rights and Obligations of USER
4.1 General Obligations
4.2 Prohibited Use
USER is prohibited from manipulating the functionality of the PIRCHE-Module or trying to extend the rights of use granted.
5. Data Protection
USER is obligated to replace the patient’s and donor’s real names with pseudonyms, and will only use personal data of patients and donors, which can identify the person as a whole, particularly his name, if valid authorization exists in this regard, in particular on the basis of data protection laws, other rules and regulations, ethical principles, or the consent of the patients and donors. USER shall be responsible for any violation of applicable data protection law.
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Version v.1.2, January 15th 2016