Donor-Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes Independently Predicts the Incidence of De Novo Donor-Specific HLA Antibodies Following Renal Transplantation (2017)

Authors of Publication: Nils Lachmann, Matthias Niemann, Petra Reinke, Klemens Budde, Danilo Schmidt, Fabian Halleck, Axel Pruß, Constanze Schönemann, Eric Spierings, and Oliver Staeck. Appeared in: American Journal of Transplantation (14th of June, epub ahead of print)   Read more…

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA (2017)

Author of Publication: Vadim Jucaud. Appeared in: Journal of Immunology Research (February 2017) Read more… Abstract The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the differentiation of B cells into plasma cells. […]

Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation (2017)

Authors of Publication: Geneugelijk K, Wissing J, Koppenaal D, Niemann M, Spierings E. Appeared in: Journal of Immunology Research (February 2017) Read more… Abstract Epitope-based HLA matching has been emerged over the last few years as an improved method for HLA matching in solid organ transplantation. The epitope-based matching concept has been incorporated in both the PIRCHE-II and the […]