PIRCHE Kidney Transplantation – Integration in Today’s Routine

Abstract Previous studies showed the beneficial effect of low PIRCHE epitope matching scores in kidney-transplanted patients. In transplantations with high PIRCHE scores, the incidence of de novo donor specific antibodies was heavily increased compared to cases with a low PIRCHE score. This suggests, optimizing for PIRCHE numbers reduces immunological risk after transplantation. Herein, we want […]

Nils Lachmann’s Poster about PIRCHE® at DTG 2016 Receives Poster Award

At the 25th DTG (Deutsche Transplantationsgesellschaft) annual meeting in Essen, Germany, the poster titled “De novo donor-specific HLA antibodies after kidney transplantation are correlated with the number of predicted indirectly recognizable epitopes” was awarded with a poster prize. Nils Lachmann and his team of co-authors proved previous findings of Eric Spierings’ working group, that increased numbers of PIRCHE correlate with the development […]

The PIRCHE® technology: Predicting HLA epitopes being indirectly recognized improves donor selection in various transplantation settings

University Medical Center (UMC) Utrecht has developed a new method to select permissible mismatches. This technology applies to hematopoietic stem cell transplantation, solid organ transplantation, and other domains improving graft acceptance and therapy effectiveness. The new technology named PIRCHE® forecasts T-cell related immune responses against HLA derived peptides after transplantation(3). In contrast to existing technologies, […]

Cord Blood Symposium 2014: Poster Award for Kirsten Thus

Kirsten Thus’ poster presented at the 12th San Francisco Cord Blood Symposium shows that “Predicted Indirectly ReCognizable HLA Epitopes (PIRCHES) correlate with chronic graft-versus-host- disease and relapse-related mortality in paediatric patients after Cord Blood transplantation”. Interestingly, the risk for cGvHD is increased with more PIRCHEs presented on HLA class II whereas lower numbers of PIRCHE […]