Matthias holds a Masters degree in Computer Science with a major in software engineering and a minor in Bioinformatics from Berlin University (Freie Universität). While working at Charité University Hospital in Berlin, he developed a database for kidney transplantation data and worked on various laboratory information systems and research databases. His research at Charité focused on epitope matching models and machine learning. He was instrumental in the implementation methods to increase data quality. Since fall 2014 he focuses at PIRCHE on further improving the PIRCHE algorithm and investigating the technology's power in new domains.

PIRCHE Kidney Transplantation – Integration in Today’s Routine

Abstract Previous studies showed the beneficial effect of low PIRCHE epitope matching scores in kidney-transplanted patients. In transplantations with high PIRCHE scores, the incidence of de novo donor specific antibodies was heavily increased compared to cases with a low PIRCHE score. This suggests, optimizing for PIRCHE numbers reduces immunological risk after transplantation. Herein, we want […]

Donor-Recipient Matching Based on Predicted Indirectly Recognizable HLA Epitopes Independently Predicts the Incidence of De Novo Donor-Specific HLA Antibodies Following Renal Transplantation (2017)

Authors of Publication: Nils Lachmann, Matthias Niemann, Petra Reinke, Klemens Budde, Danilo Schmidt, Fabian Halleck, Axel Pruß, Constanze Schönemann, Eric Spierings, and Oliver Staeck. Appeared in: American Journal of Transplantation (14th of June, epub ahead of print)   Read more…

The Immunogenicity of HLA Class II Mismatches: The Predicted Presentation of Nonself Allo-HLA-Derived Peptide by the HLA-DR Phenotype of the Recipient Is Associated with the Formation of DSA (2017)

Author of Publication: Vadim Jucaud. Appeared in: Journal of Immunology Research (February 2017) Read more… Abstract The identification of permissible HLA class II mismatches can prevent DSA in mismatched transplantation. The HLA-DR phenotype of recipients contributes to DSA formation by presenting allo-HLA-derived peptides to T-helper cells, which induces the differentiation of B cells into plasma cells. […]

Computational Approaches to Facilitate Epitope-Based HLA Matching in Solid Organ Transplantation (2017)

Authors of Publication: Geneugelijk K, Wissing J, Koppenaal D, Niemann M, Spierings E. Appeared in: Journal of Immunology Research (February 2017) Read more… Abstract Epitope-based HLA matching has been emerged over the last few years as an improved method for HLA matching in solid organ transplantation. The epitope-based matching concept has been incorporated in both the PIRCHE-II and the […]

Nils Lachmann’s Poster about PIRCHE® at DTG 2016 Receives Poster Award

At the 25th DTG (Deutsche Transplantationsgesellschaft) annual meeting in Essen, Germany, the poster titled “De novo donor-specific HLA antibodies after kidney transplantation are correlated with the number of predicted indirectly recognizable epitopes” was awarded with a poster prize. Nils Lachmann and his team of co-authors proved previous findings of Eric Spierings’ working group, that increased numbers of PIRCHE correlate with the development […]