Presented: DRB3/4/5, DQA1, DPA1, MICA and MICB
We are happy to announce, that DRB3/4/5, DQA1, DPA1, MICA and MICB are now supported as peptide sources. Mismatches between patient and donor occurring on these loci will be included in the PIRCHE analysis. This allows us to predict foreign allo-peptides even for 5- or 6-loci matched cases. This update is now available to all PIRCHE csv modules.
The solid organ PIRCHE modules are now showing you the PIRCHE score per locus, per presenting molecule and even per mismatch. This allowed us to consider identical peptides from different mismatches as duplicates, giving more precise scores.
All on board the tour bus
You don’t know what modules there are? Now you’ll find previews for all available PIRCHE modules in the sidebar. But if you like, we can also show you around: Take the tour and see what’s there and how it’s used.
Our extrapolation of low resolution typings now allows you to select between serologic and molecular typing inputs. This improves accuracy of imputation and therefore refines overall prediction.
Since fall 2014 he focuses at PIRCHE on further improving the PIRCHE algorithm and investigating the technology's power in new domains.
Latest posts by Matthias Niemann (see all)
- Paper on PIRCHE-II in kidney transplantation featured on Transplant Campus - January 24, 2018
- Dutch Society for Immunology awards Eric Spierings for PIRCHE - December 28, 2017
- Tech Newsletter #2: More loci, more assistance, more details - September 25, 2017